Buprenorphine Plus Baclofen to Increase Analgesia in Healthy Volunteers

• Status: Recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine if baclofen will enhance buprenorphine analgesia for acute pain in healthy volunteers.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham
• Treatments: Baclofen; Buprenorphine

Criteria

Inclusion Criteria:

• 18 years or older

• general good health

• English speaking

Exclusion Criteria:

• Pregnant or nursing

• Opioid use disorder or any substance use disorder other than nicotine

• Prescribed agonist treatment for opioid dependence or prescribed opioids for a medical condition

• Prescribed naltrexone

• Known sensitivity to buprenorphine, naloxone, or baclofen

• Acute or chronic pain condition

• Trouble breathing or a pulmonary condition

• Prescribed benzodiazepines or daily use of benzodiazepines

• Cognitive impairment or psychiatric disorder requiring treatment