Bupropion as a Smoking Cessation Aid in Alcoholics

• Status: Completed
• Trial end date: 2005-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test the use of time-released bupropion (Wellbutrin) in patients receiving treatment for alcohol abuse/dependence as an aid to stop smoking. Patients will receive either a time-released bupropion or placebo. Both groups will receive nicotine replacement therapy during the 9 week study. A final followup assessment will be conducted 6 months from the start of treatment.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Treatments: Bupropion

Criteria

Inclusion Criteria:

• Currently a patient in the Omaha VA Medical Center, Substance Abuse Treatment Center (SATC) or at Catholic Charities Campus for Hope.

• Have a diagnosis of alcohol abuse or alcohol dependence.

• Smoke 20 or more cigarettes/day (may also smoke pipes/cigars).

• Be interested in quitting smoking.

• Provide name, addresses, and phone numbers of at least two individuals who can provide information on their alcohol, nicotine, and other drug use during the follow-up period.

• If female, patient must a) be of non-childbearing potential, b) have a negative pregnancy test, c) sign a document stating they do not plan on becoming pregnant during the study.

• Agree to sign informed consent.

• Able to read and understand study-related forms and procedures.

Exclusion Criteria:

• Advanced cardiac, pulmonary, renal, or liver disease.

• History of seizures.

• History of brain tumor or significant head trauma.

• History of bulimia or anorexia nervosa.

• Current major depressive disorder or past history of panic disorders, schizophrenia, or bipolar affective disorder.

• Using psychoactive drugs.

• Receiving treatment with medications that lower seizure thresholds.

• Use of an investigational drug in any study in the past four weeks.

• Currently using any asthma medication.

• Used time-released bupropion in the past 12 months.

• Currently using any other treatments to stop smoking.