Bupropion in Sexual Dysfunction Among Methadone Maintenance Treatment Men

• Status: Completed
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to assess the tolerability, safety, and efficacy of bupropion hydrochloride sustained-release in the treatment of sexual dysfunction in men on methadone maintenance therapy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Malaya
• Treatments: Bupropion; Methadone

Criteria

Inclusion Criteria:

• Had a diagnosis of opioid dependence base on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria

• While taking a stable dose of methadone In UMMC (University Malaya Medica Centre) and University Malaya centre of Addiction Science (UMCAS) outpatient clinic for ≥ 6 months

• Were experiencing constant sexual dysfunction for ≥ 4 weeks

• Were in a stable sexual relationship with a female partner for ≥ 6 months

Exclusion Criteria:

• Severe behavior disturbances or psychotic symptoms

• Obvious organic illnesses caused the sexual dysfunction (such as diabetics or patients with heart and vascular disease)

• Those with history of sexual dysfunction before methadone therapy

• Receiving antiviral treatment for viral hepatitis or HIV, or androgen replacement treatment.

• History of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy)

• Using other psychotropic medications other than methadone

• Clinical significant abnormal laboratory values.

• Clinically significant abnormal ECG. Documented history of other psychiatric diagnosis (schizophrenia, bipolar disorder, major depressive disorder, organic brain disorder, dementia etc.)

• Refused to give participate.