Burn Healing and Analgesia With Propranolol

• Status: Completed
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the ability of propranolol to decrease pain and improve recovery in burn patients with a common genotype.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of North Carolina, Chapel Hill
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• Thermal burn

• Greater than or equal to 18 years of age

• Less than 60 years of age

• Able to speak and read English

Exclusion Criteria:

• Intubated

• Clinically unstable

• Other substantial comorbid injury (e.g. long bone fracture)

• Heart block greater than first degree (EKG)

• History of coronary artery disease

• History of congestive heart failure

• Asthma (within past 10 years, induced by a beta-blocker, or receiving current treatment)

• Pregnant

• Prisoner

• Psychotic, suicidal, or homicidal

• Diabetic

• Hepatic failure (acute or chronic)

• Renal failure (acute or chronic)

• History of hyperthyroidism unless taking synthroid or other thyroid hormone replacement

• Exceeds daily acceptable chronic opioid use prior to burn

• Interacting medication

• Received propranolol within the last 6 months

• Multiple severe allergic reactions

• On daily methylphenidate or similar stimulant medication

• Unwilling to use medically acceptable birth control (if childbearing potential)

• Breastfeeding

• Severe peripheral vascular disease or vasospastic disorder

• Bradycardia that in the opinion of the investigator would constitute too great a risk when considered in the context of the patient's medical comorbidities and health history

• Other criteria that in investigator's opinion makes participant poor candidate for the trial

• Cancer (except basal cell cancer)