CD19.CAR Allogeneic NKT for Patients With Relapsed or Refractory B-Cell Malignancies (ANCHOR)
Status:
Recruiting
Trial end date:
2035-03-01
Target enrollment:
Participant gender:
Summary
This study is for patients who have lymphoma or leukemia that has come back or has not gone
away after treatment. Because there is no standard treatment for this cancer, patients are
being asked to volunteer for a gene transfer research study using special immune cells.
The body has different ways of fighting infection and disease. No single way seems perfect
for fighting cancers. This research study combines two different ways of fighting disease,
antibodies and immune cells. Antibodies are types of proteins that protect the body from
bacteria and other diseases. Immune cells, also called lymphocytes, are special
infection-fighting blood cells that can kill other cells including tumor cells. Both
antibodies and lymphocytes have been used to treat patients with cancer. They have shown
promise, but have not been strong enough to cure most patients.
The antibody used in this study is called anti-CD19. This antibody sticks to lymphoma cells
because of a substance on the outside of the cells called CD19. CD19 antibodies have been
used to treat people with lymphoma and leukemia. For this study, the anti-CD19 antibody has
been changed so that instead of floating free in the blood it is now joined to the NKT cells,
a special type of lymphocytes that can kill tumor cells but not very effectively on their
own. When an antibody is joined to a T cell in this way it is called a chimeric receptor.
Investigators have also found that NKT cells work better if proteins are added that stimulate
lymphocytes, such as one called CD28. Adding the CD28 makes the cells last for a longer time
in the body but maybe not long enough for them to be able to kill the lymphoma cells. It is
believed that by adding an extra stimulating protein, called IL-15, the cells will have an
even better chance of killing the lymphoma cells.
In this study the investigators are going to see if this is true by putting the anti-CD19
chimeric receptor with CD28 and the IL-15 into NKT cells grown from a healthy individual.
These cells are called ANCHOR cells. These cells will be infused into patients that have
lymphomas or leukemias that have CD19 on their surface. The ANCHOR cells are investigational
products not approved by the Food and Drug Administration.
The purpose of this study is to find the biggest dose of ANCHOR cells that is safe, to see
how long the ANCHOR cells last, to learn what their side effects are and to see whether this
therapy might help people with lymphoma or leukemia.
Phase:
Phase 1
Details
Lead Sponsor:
Baylor College of Medicine
Collaborators:
Center for Cell and Gene Therapy, Baylor College of Medicine Texas Children's Hospital The Methodist Hospital Research Institute The Methodist Hospital System