CDP-Choline and Working Memory After TBI: A Neuroimaging Study
Status:
Completed
Trial end date:
2013-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether an investigational drug, called
"CDP-Choline", improves memory in people with traumatic brain injury (TBI). To do this, we
are asking for people with traumatic brain injury and people without traumatic brain injury
to be a part of this study. We will compare results between each group to see if this
investigational drug makes a difference with memory. We will also compare brain imaging
results and information collected before and after the taking of the study medication to see
if there are any differences. We hypothesize that there will be differences in brain
activation patterns between individuals with TBI and healthy controls, as well as differences
in performance on memory testing at baseline. We further hypothesize that, after treatment
with CDP-Choline, the patterns in neuroimaging findings and cognitive testing results for
individuals with TBI will more closely resemble results observed for healthy individuals. We
hope that what we learn from this study will be helpful in the future treatment of
individuals with head injury.
Phase:
Phase 2
Details
Lead Sponsor:
Patricia M. Arenth University of Pittsburgh
Collaborators:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institutes of Health (NIH)