CELECOXIB Plasma and Cerebral Spinal Fluid Pharmacokinetics in Children
Status:
Not yet recruiting
Trial end date:
2024-01-01
Target enrollment:
Participant gender:
Summary
Celecoxib is effective for reducing postoperative pain in adults. Children use celecoxib more
rapidly than adults and require higher doses. Celecoxib is partially metabolized in the liver
by a certain enzyme. A person's genetic variation of this enzyme can influence how well their
body uses Celecoxib. Furthermore, Celecoxib down-regulates P-glycoprotein (P-gp), a drug
efflux transporter located at the blood brain barrier responsible for central nervous system
(CNS) extrusion of ondansetron and possibly fentanyl; therefore celecoxib may augment the CNS
effects of these drugs.
Understanding the blood and cerebrospinal fluid (CSF) profile of celecoxib in children and
the influence of genetics on metabolism would help to develop appropriate celecoxib dosing in
children for various treatment options.