Neonates presenting with neurologic symptoms require rapid, non-invasive imaging with high
spatial resolution and tissue contrast. The purpose of this study is to evaluate brain
perfusion using contrast-enhanced ultrasound CEUS in bedside monitoring of neonates and
infants with hypoxic ischemic injury. Investigational CEUS scan will be performed separately
from clinically indicated conventional US, in the ICU. Subjects will be scanned with CEUS at
two different time-points (at the time HII is first suspected or diagnosed and at time of MRI
scan), separately from clinically indicated ultrasound. The CEUS scan will be interpreted by
the sponsor-investigator.
The study will be conducted at one site, The Children's Hospital of Philadelphia. It is
expected that up to 100 subjects will be enrolled per year, for up to two years, for a total
enrollment of up to 200 subjects.