CI(R)CA : Coumadin Interaction With Rofecoxib, Celecoxib and Acetaminophen
Status:
Completed
Trial end date:
2009-09-01
Target enrollment:
Participant gender:
Summary
Coumadin drug-drug interactions (DDI) are frequent. Patients in permanent use of coumadin are
advised to avoid traditional nonsteroidal antiinflammatory drugs to avoid risk of bleeding.
New selctive cyclooxygesase 2 inhibitors arisen as potential option for treating pain and
inflamation in these patients once interactions with coumadin are supposed to be lower. The
CI(R)CA study was made to evaluate in a prospective fashion the occurrence of DDI with new
cyclooxygenase antiinflammatory drugs and coumadin when compared to acetaminophen and
placebo.