CIRcadian Rhythms and CortisoL. Effects on Substrate Metabolism and Clock Gene Expression and Functioning
Status:
Recruiting
Trial end date:
2024-03-01
Target enrollment:
Participant gender:
Summary
The aim of this project is to study the effects of exogenous glucocorticoid exposure on
substrate metabolism, energy expenditure and correlates of circadian rhythmicity in healthy
adults. The hypotheses are:
Short-term high dose glucocorticoid exposure in healthy subjects disrupts:
- The inherent circadian pattern of the respiratory exchange ratio and REE
- Sleep quality, appetite and food intake
- Clock gene expression and function in adipose tissue, skeletal muscle and blood
leukocytes