Overview

CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee

Status:
Not yet recruiting

Trial end date:
2025-10-01

Target enrollment:
0

Participant gender:
All

Summary

The goal of this clinical trial is to compare two types of solutions (chlorhexidine gluconate-alcohol solution or povidone-iodine solution) that help eliminate harmful bacteria on the skin at the time of surgery. The main outcome of interest is: • the need for re-operation for a wound complication or an infection of the prosthetic joint within one year after surgery. Participants will be contacted at two time points after surgery to complete a 5-minute survey: after 30 days, and after 1 year. If you decide to participate, you will be randomly assigned (like flipping a coin) by a computer, to one of the possible interventions. You will be told which group you have been assigned to.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Sunnybrook Health Sciences Centre

Treatments:

Anti-Infective Agents, Local
Chlorhexidine

Criteria

Inclusion Criteria:

1. Aged 18 years or older

2. Scheduled to undergo aseptic revision total hip arthroplasty or total knee
arthroplasty with exchange of at least one prosthetic component

Exclusion Criteria:

1. Revision for prosthetic joint infection or wound complication

2. Known history of previous prosthetic joint infection in the operative joint

3. Any degree of clinical concern for prosthetic joint infection

4. History of allergy to iodine, chlorhexidine, or alcohol