COlchicine for the Prevention of Post Electrical Cardioversion Recurrence of AF
Status:
Withdrawn
Trial end date:
2018-09-02
Target enrollment:
Participant gender:
Summary
There is substantial evidence linking inflammation to the initiation and perpetuation of AF.
Although the precise mechanism by which inflammation contributes to the development of AF
remains unclear, it has been proposed that inflammation may lead to "atrial myocarditis" with
subsequent electrical and structural changes involving both atrial myocytes and extracellular
matrix, leading finally to initiation and maintenance of AF. The high incidence of AF in
post-operative cardiac surgeries, a state of intense inflammatory process, points out this
association. Similarly, in non operative AF, inflammation appears to play a prominent role in
both etiology and maintenance of AF. Indeed an increase of inflammatory markers to both
paroxysmal and persistent AF was shown by numerous studies.