CP4071 in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of CP4071 in treating patients who have locally advanced or metastatic soft tissue sarcoma.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Herbert Irving Comprehensive Cancer Center
• Collaborator: National Cancer Institute (NCI)
• Treatments: Digitoxin

Criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed soft tissue sarcoma

• Metastatic or locally advanced

• Failed at least 1 prior therapy

• Measurable disease outside prior irradiation field

• No CNS metastases

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• SWOG 0-2

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• Bilirubin no greater than 2 times upper limit of normal (ULN)

Renal:

• Creatinine less than 1.5 times ULN

• Calcium less than ULN

• Potassium normal

Other:

• No other malignancy within the past 5 years except stage I or II cancer in complete remission, carcinoma in situ of the cervix, or basal cell or squamous cell skin cancer

• Not pregnant or nursing

• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Prior biologic response modifier therapy allowed

Chemotherapy:

• No more than 3 prior chemotherapy regimens for advanced, recurrent, or metastatic disease

• No other concurrent chemotherapy

Endocrine therapy:

• No concurrent hormonal therapy for malignancy

Radiotherapy:

• See Disease Characteristics

• At least 3 weeks since prior radiotherapy and recovered

• No concurrent radiotherapy

Surgery:

• At least 4 weeks since prior surgery and recovered

Other:

• No other concurrent cardiac glycosides