CRF - Nociceptin Receptor Interactions

• Status: Completed
• Trial end date: 2019-06-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine if [C-11]NOP-1A receptor binding (VT) can be altered by an intravenous hydrocortisone (cortisol) challenge through CRF-NOP interactions

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pittsburgh
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Corticotropin-Releasing Hormone; Cortisol succinate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Nociceptin; Nocistatin

Criteria

Inclusion Criteria:

• Males or females between 18 and 40 years old

Exclusion Criteria:

• Current DSM-5 psychiatric disorders

• Binge drinking as defined in NIAAA criteria in the past month

• Recreational abuse of opiates, sedative-hypnotics, cocaine, amphetamines, MDMA, and PCP, as well as cannabis use

• Currently on any prescription medical or psychotropic medication;

• Current or past severe medical, endocrine, cardiovascular, immunological or neurological illnesses

• Currently pregnant or breast-feeding;

• History of radioactivity exposure via prior nuclear medicine studies or occupational exposure in past twelve months

• Metallic objects in the body that are contraindicated for MRI;

• First-degree relative with psychosis or mood disorders