CSE v. Epidural for Postpartum Depression

• Status: Completed
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this pilot prospective randomized control trial is to compare the initiation of labor epidural analgesia by combined spinal epidural vs. epidural for the influence on risk for postpartum depression symptoms. Investigators will randomize women to the receipt of CSE or E during labor, after measuring baseline psychological, psychosocial, and psychophysical factors related to pain and depression. The immediate research goals are to understand whether the association between labor pain and PPD is modifiable through the use of tailored anesthetic techniques.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Grace Lim, MD, MS
• Treatments: Bupivacaine; Fentanyl

Criteria

Inclusion Criteria:

• Nulliparous (no prior childbirth)

• Singleton gestation

• Third trimester

• Healthy pregnancy

• English proficiency (surveys validated in English)

• Planned vaginal delivery

• Planning to use labor epidural analgesia

• Term delivery (>/= 37.0 weeks)

Exclusion Criteria:

• Severe maternal disease

• Severe fetal disease

• Delivery not at term (delivery prior to 37.0 weeks)

• Contraindications to neuraxial anesthesia known at the time of enrollment

• Cesarean delivery WITHOUT labor

• Planning to list infant for adoption

• Did not receive epidural analgesia (either CSE or E) for labor