CST1 Predictive Model of Oral Glucocorticoid Therapy Sensitivity for Chronic Rhinosinusitis With Polyps
Status:
Not yet recruiting
Trial end date:
2025-11-01
Target enrollment:
Participant gender:
Summary
Topical and systemic steroids constitute the first choice in medical treatment for nasal
polyps. Glucocorticoids sensitivity is significantly correlated with CST1 level in nasal
secretions. The goal of this single-arm clinical trial based on a multicenter platform is to
test CST1 in patients with chronic rhinosinusitis and nasal polyps before and after oral
glucocorticoid therapy. Endoscopic polyp score, Total Nasal Symptom Score(TNSS), SNOT-22
score and other biomarkers are also evaluated before and after the treatment. Researchers
will develop a CST1 predictive model of oral glucocorticoid therapy for Chronic
Rhinosinusitis with Polyps.