CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera
Status:
Recruiting
Trial end date:
2023-10-01
Target enrollment:
Participant gender:
Summary
This is an open-label, non-randomized study. The purpose of this study is to better
understand how vaccines against typhoid fever and cholera affect the normal immune system and
bacteria in the intestine. Patients having standard-of-care endoscopies (colonoscopy and/or
esophagogastroduodenoscopy (EGD)) will be divided into 3 groups:
Group 1: Vivotif typhoid vaccination and/or Vaxchora cholera vaccination then endoscopy Group
2: Endoscopy, then Vivotif typhoid vaccination and/or Vaxchora cholera vaccination, then
follow-up endoscopy Group 3: Endoscopy without vaccination.
Both vaccines used in this study are licensed by the Food and Drug Administration (FDA) for
travelers to developing countries. Volunteers will be asked to donate tissue, blood, saliva
and stool samples for studying how the body responds to the typhoid and/or cholera vaccine.
Phase:
Phase 4
Details
Lead Sponsor:
University of Maryland University of Maryland, Baltimore