Cadaveric Islet Transplantation in Patients With Insulin-Dependent Diabetes Mellitus
Status:
Terminated
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
We hypothesize that the following improvements to islet transplantation will increase the
islet mass successfully isolated and allow for engraftment from a single pancreas. The
improvements are:
- Using Two-Layer method preservation to improve pancreas quality before islet isolation
- Maintaining isolated islets in culture before transplantation
- Using a steroid-free immunosuppression regimen
- Transplanting the best combination of donor and recipient possible after HLA screening
and final crossmatching