Cadonilimab + FOLFOX Versus FOLFOX in the Neoadjuvant Treatment of pMMR/MSS Locally Advanced Colorectal Cancer
Status:
Recruiting
Trial end date:
2028-11-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to compare the efficacy and safety of the combination of
Cadonilimab and FOLFOX regimen compared to FOLFOX regimen alone in the neoadjuvant
chemotherapy of pMMR/MSS locally advanced colorectal cancer. The main question aims to answer
are:
Question 1: Compare the pathological complete response rate between the combination of
Cadonilimab and FOLFOX regimen and the FOLFOX alone.
Question 2: Compare the survival outcomes and safety between the combination of Cadonilimab
and FOLFOX regimen and the FOLFOX alone.
Two groups of participants will receive different new adjuvant chemotherapy regimens, and
their efficacy will be compared.
Phase:
Phase 2
Details
Lead Sponsor:
Cancer Institute and Hospital, Chinese Academy of Medical Sciences