Caffeine vs. ALA in BMS Treatment. (BMS: Burning Mouth Syndrome. ALA: Alpha-Lipoic Acid.)

• Status: Completed
• Trial end date: 2023-06-23
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to evaluate the efficacy of caffeine and alpha-lipoic acid in the treatment of burning mouth syndrome by symptom assessment with visual analogue scale.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lu Jiang
• Treatments: Caffeine; Thioctic Acid

Criteria

Inclusion Criteria:

• Adults over 18 years of age

• Diagnosis of BMS according to the 3rd edition of the International Classification of Headache Disorders (ICHD-3)

• Daily intraoral burning or dysaesthesia lasting for more than 2 hours for over 3 months

• Normal oral mucosa and sensory testing

• Condition not better accounted for by another ICHD-3 diagnosis

Exclusion Criteria:

1. Secondary BMS due to local or systemic disorders

2. Prior treatment for BMS

3. Psychiatric or progressive neurological disorders

4. Systemic disorders potentially associated with oral disease

5. Long-term history of smoking, drinking, or medication use

6. Consumption of caffeinated products

7. Poor oral hygiene

8. Abnormal blood test results (including blood count, glucose, serum iron, ferritin and transferrin, folic acid, or vitamin B12 levels)

9. Incomplete medical records

10. Unwillingness to participate