Camrelizumab in Combination With Apatinib and Temozolomide as First-line Treatment in Advanced Acral Melanoma

• Status: Not yet recruiting
• Trial end date: 2027-02-15
• Target enrollment: 0
• Participant gender: All

Summary

It is a RCT aimed to evaluate the Progression Free Survival of Camrelizumab combined with apatinib and temozolomide as First Line Therapy in Advanced Acral Melanoma.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University Cancer Hospital & Institute
• Treatments: Apatinib

Criteria

Inclusion Criteria:

• age:≥18 years, male or female.

• Histopathologically confirmed recurrence, inoperable resection or metastatic acral melanoma (stage III/IV).

• Has not received any systematic anti-tumor drug treatment.

• Measurable disease based on Response Evaluation Criteria In Solid Tumors (RECIST) 1.1.

• ECOG 0-1.

• Adequate organ function.

• Life expectancy of greater than 12 weeks.

• Patient has given written informed consent.

Exclusion Criteria:

• Patients who have or are currently undergoing additional chemotherapy, radiation therapy, targeted therapy or immunotherapy.

• Known history of hypersensitivity to macromolecular protein preparation or any components of the drug formulation.

• Subjects before or at the same time with other malignant tumors (except which has cured skin basal cell carcinoma and cervical carcinoma in situ);

• Subjects with any active autoimmune disease or history of autoimmune disease Uncontrolled clinically significant heart disease, including but not limited to the following: (1) > NYHA II congestive heart failure; (2) unstable angina, (3) myocardial infarction within the past 1 year; (4) clinically significant supraventricular arrhythmia or ventricular arrhythmia requirement for treatment or intervention;

• Received a live vaccine within 4 weeks before the first dose of study medication.

• Pregnancy or breast feeding.

• Decision of unsuitableness by principal investigator or physician-in charge.