Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?

• Status: Recruiting
• Trial end date: 2025-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This proof-of-principle study will determine if breathing an increased concentration of oxygen above the concentration in normal room air results in changes in the sensory and motor function in people with subacute or chronic, severe spinal cord injury (SCI).

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alberta
• Collaborator: Canadian Institutes of Health Research (CIHR)

Criteria

Inclusion Criteria:

1. Individuals with traumatic SCI with onset ≥3 months prior,

2. Between 18 - 65 yr old,

3. ASIA Impairment Scale at discharge classified as A, B or C,

4. Injury level between C5 and T10,

5. Able to give informed, written consent.

Exclusion Criteria:

1. Frequent uncontrolled autonomic dysreflexia,

2. Uncontrolled high blood pressure,

3. Cardiac or cardiovascular disease,

4. Cancer,

5. Active urinary tract infection,

6. Active pressure sores,

7. Signs of deep vein thrombosis in the legs,

8. Severe swelling of the feet and/or legs,

9. Severe cognitive impairment,

10. Pulmonary dysfunction such as chronic obstructive pulmonary disease or acute respiratory infection,

11. Any condition which would be exacerbated by sitting or lying in one position for 2 hours, such as low back pain

12. Pregnancy.