Can Epinephrine Coated Syringe for Subcutaneous Immunotherapy (SCIT) Reduce Large Local Reaction?
Status:
Completed
Trial end date:
2019-09-01
Target enrollment:
Participant gender:
Summary
Allergen immunotherapy is effective in the management of allergic asthma, allergic
rhinitis/conjunctivitis, and stinging insect hypersensitivity. The most common side effect of
subcutaneous allergen specific immunotherapy (SCIT) is local reactions (LR). Although some
studies indicated that LR did not predict systemic reaction (SR), patients with higher
frequency of large local reaction (LLR) were reported to have higher risk for SR. Epinephrine
may decrease LLR due to its vasoconstrictive effect . The objective of this study was to
compare the size of LLR in patients receiving SCIT with epinephrine or normal saline coated
syringe. The patients who complained of frequent LLR despite pre-medication and local
treatment were recruited.