Can Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?
Status:
Completed
Trial end date:
2015-01-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to examine whether two clinically sensible dose regimen of
fentanyl (low dose vs. high dose) lead to different pain scores as measured by the nonverbal
rating scale (NRS) in healthy volunteers at 4.5 to 6.5 hours after fentanyl application. Pain
modalities tested will include transdermal electrical stimulation and cold pressor pain.
The investigators hypothesize that the high dose fentanyl group will have an increase of
approximately 20% in the NRS.