Can the Health Benefits of a Walking-based Exercise Programme be Enhanced by Co-ingestion of a Lipid-lowering Drug?

• Status: Suspended
• Trial end date: 2023-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Study investigates the hypothesis that an exercise programme of steady walking will have larger effects on insulin sensitivity and glycemic control when combined with Acipimox intake prior to each exercise session in people with pre-diabetes. Thirty-four sedentary, overweight/obese people (aged 25-50 years, BMI >28 kg.m-2) with pre-diabetes will be recruited using the same strategy as study 2 and split into two groups (detailed below). Participants will undergo several pre- intervention assessments, followed by a 12-week walking based intervention combined with either Acipimox ingestion or no drug ingestion, pre- each exercise session. Following this, the post-assessment measures will identical to the pre-assessment measures.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Liverpool John Moores University
• Collaborators: Aintree University Hospitals NHS Foundation Trust; Diabetes UK; Liverpool University Hospitals NHS Foundation Trust; Royal Liverpool University Hospital
• Treatments: Acipimox; Hypolipidemic Agents; Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• BMI >28 kg.m-2

• Pre-diabetic

• Not currently using any anti-diabetes medication

• Physically inactive (performing less than two 30 min structured exercise sessions per week for the last year)

• Not pregnant or currently breast feeding

• Pre-menopausal

• Not currently involved in a weight loss programme or using weight loss medication

Exclusion Criteria:

• Involved in regular exercise (engaged in more than 2 sessions of structured exercise of >30 min per week)

• Currently using anti-diabetes medication (e.g. insulin, metformin)

• Currently using niacin/vitamin B3 supplements

• Pregnant or breast feeding

• Currently engaged in active weight loss programme or using weight loss medication

• Diagnosed with chronic kidney disease