Overview

Canagliflozin With Gemcitabine in Pancreatic Carcinoma

Status:
Not yet recruiting

Trial end date:
2027-03-31

Target enrollment:
0

Participant gender:
All

Summary

Gemcitabine-based chemotherapy or combination with FOLFIRINOX is the leading treatment of pancreatic cancer. However, the overall response rate of pancreatic cancer to gemcitabine is less than 20%. Resistance to gemcitabine is the most important reason. There is an urgent need to develop new combination therapies to improve the efficiency of chemotherapy, avoid toxicity limitations, and improve the overall prognosis of pancreatic cancer. At present, it has been found that canagliflozin can reduce the expression level of PD-L1 in pancreatic cancer and restore the vitality of CD8+ T cells. Canagliflozin combined with gemcitabine may improve the efficiency of chemotherapy.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Zhang Xiaofeng,MD

Collaborators:

College of Pharmaceutical Sciences at Zhejiang University
The Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University

Treatments:

Canagliflozin
Gemcitabine

Criteria

1. Inclusion criteria: # Age ≥18 years old; #Metastatic or unresectable pancreatic cancer
is confirmed through histology or cytology; # Estimated survival time > 3 months; #
Without any chemotherapy treatment or more than one month from the end of the last
chemotherapy course; #ECOG physical status score 0-2;

2. Exclusion criteria: # patients who had allergic reaction to therapeutic drugs; #
patients with other types of cancer; # Patients with severe diseases of heart, liver,
kidney, etc.; (4) gastrointestinal dysfunction or unable to oral medication.

3. Shedding/eliminating criteria: exiting in the midway; Lost to follow-up during the
follow-up period; Treatment was not continued according to the treatment protocol.