Cancer Treatment Followed by Surgery for Early Stage Non-small Cell Lung Cancer
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
- The purpose of the phase I portion of the study is to determine the safety and
feasibility of neoadjuvant bortezomib in combination with docetaxel and cisplatin
followed by surgery in early stage non-small cell lung cancer, via a multi-cohort dose
escalation trial.
- The phase II portion of the study will look at the clinical response rate and the
pathology response rate. Other purposes are to look at surgical morbidity, mortality and
respectability rates. Molecular correlates of response and survival to this neoadjuvant
regimen will be explored.