Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia

• Status: Recruiting
• Trial end date: 2022-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether anesthesia maintained with propofol results in better one- and five-year-survival than anesthesia maintained with sevoflurane.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Uppsala University
• Collaborators: Air Force Military Medical University, China; Helsingborgs Hospital; Kalmar County Hospital; Karlstad Central Hospital; Lund University Hospital; Peking University First Hospital; Region Örebro County; Renji Hospital, Shanghai; Skellefteå lasarett; Sundsvall Hospital; University Hospital "Sestre Milosrdnice"; University Hospital, Linkoeping; Uppsala University Hospital; Växjö Hospital; Wroclaw Medical University
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Be informed of the nature of the study and have provided written informed consent

• At least 18 years of age

• Patient that is scheduled for elective radical breast- or colorectal cancer surgery in general anesthesia. Radical surgery means that the aim of the surgery is to cure (adjuvant treatment such as chemotherapy and/or radiation therapy seen as part of the curative treatment).

Exclusion Criteria:

• The surgery that is going to be made is an acute surgical procedure

• The surgery that is going to be made is palliative surgery

• Known or suspected hypersensitivity to either propofol or sevoflurane or presence of any contraindication according to the substances' valid summary of product characteristics.

• Lack of suitability for participation in the trial, for any reason, as judged by the Investigator (e.g. communicative disturbances (language or intellectual)).