Cannabidiol Effects on Cardiovascular System and Exercise Responses

• Status: Not yet recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To identify the autonomic effects of recreationally-relevant doses of cannabidiol (CBD) in an older population, and to evaluate the effect of CBD on exercise performance and recovery.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Castleton University
• Treatments: Cannabidiol

Criteria

Inclusion Criteria:

• male or female

• 18+ years (aims 3&4)

• 50+ years (aims 1&2)

• participants must agree to fast for 4 hours and abstain from food or beverages containing alcohol, caffeine, or CBD for 12 hours prior to each experimental session

• participants must agree to avoid exercise for 6 hours prior to each experimental session

• completion of Health History Screening Questionnaire with report indicating overall good health

• ability to comprehend and satisfactorily comply with protocol requirements

• written informed consent given prior to study participation

• low-risk for VO2max testing (aims 3&4)

Exclusion Criteria:

• women who are pregnant or lactating

• participants who have a history of adverse reactions to cannabidiol

• current medications that might influence the cardiovascular and/or autonomic systems

• any cardiac, pulmonary, renal, or metabolic disease

• walking difficulty (aims 3&4)

• waiting for a stress test for a medical reason (aims 3&4)

• medical contraindication to performing a treadmill stress test (aims 3&4)