Overview

Cannabidiol Effects on Fear Extinction in Social Phobia

Status:
Not yet recruiting
Trial end date:
2024-12-31
Target enrollment:
0
Participant gender:
All
Summary
The investigators will randomly assign participants with social anxiety disorder to receive oral cannabidiol (CBD) or placebo. Participants will undergo a fear conditioning and extinction trial, and the investigators will examine whether CBD increases the degree of fear reduction during extinction.
Phase:
Early Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Hartford Hospital
Treatments:
Cannabidiol
Criteria
Inclusion Criteria:

1. Age 18 and above

2. Any gender

3. Any race/ethnicity

4. Primary diagnosis of SAD according to the DIAMOND

5. At least moderate severity of SAD as evidenced by a DIAMOND severity rating of 4
(moderate) or higher

6. Able to speak, read and write English (this is necessary because the study measures
are only validated in English)

7. Concurrent medications will be allowed so long as there is not a substantial risk of
interaction with CBD

8. Able/willing to consent to participate in study

Exclusion Criteria:

1. <18 years old

2. Active substance use disorder or mania according to the DIAMOND

3. Severe risk of suicide or non-suicidal self-injury in the interviewer's judgment

4. Current or past schizophrenia spectrum disorder according to the DIAMOND

5. Developmental disability, including autism spectrum disorder, according to clinical
interview

6. History of organic brain illness or head injury with loss of consciousness > 5 minutes

7. Liver function abnormalities as detected by liver functioning test

8. History of allergic reaction to CBD according to clinical interview

9. Unable or unwilling to abstain from CBD or tetrahydrocannabinol use for 24 hr prior to
study participation

10. Pregnancy or lack of adequate contraception

11. Any clinical factors that would preclude the participant from providing informed
consent or otherwise participating in the research, according to the interviewer's
judgment