Cannabidiol Oil Extract for Prevention of Postoperative Nausea and Vomiting

• Status: Recruiting
• Trial end date: 2024-02-29
• Target enrollment: 0
• Participant gender: Female

Summary

Cannabidiol oil has been shown to be effective in treating chemotherapy induced nausea and vomiting, but there is limited information on its usefulness in nausea and vomiting that can occur after surgery. The goal of this study is to determine the effect of Cannabidiol oil on the frequency of nausea and vomiting in the first 24 hours after a gynaecological procedure. Other effects that will be assessed will include:

1. The effect of Cannabidiol oil on the level of pain and amount of pain medications needed in the first 24 hours after a gynaecological operation.

2. The effect of Cannabidiol oil on patients' overall satisfaction with the anaesthetic experience.

Some participants will be administered Cannabidiol oil under the tongue two to three hours before their procedure and an equal number will receive a placebo oil, similar in taste. This will be done randomly to minimise introducing bias. We will then compare both groups in the postoperative period to see if the Cannabidiol oil made any difference.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of The West Indies
• Treatments: Cannabidiol

Criteria

Inclusion Criteria:

All patients for elective gynaecological surgical procedures under general anaesthesia at the Main operating theatre, UHWI between the ages of 18-65 years.

Exclusion Criteria:

• Reported allergy to cannabis/CBD by products, coconut oil, peppermint oil

• Patients < 18 years

• Patients experiencing disease related nausea and vomiting

• Patients with psychological/psychiatric illnesses which prevent communication or impairs their ability to give informed consent

• Patients undergoing regional anaesthesia

• Contraindication to medicinal cannabis such as unstable cardiovascular disease, substance use disorder, or significant mental health disorder

• Cannabis use within 30 days of surgery

• Pregnancy