The aim of the study is to evaluate the efficacy of using combination of Urea-based cream
(CARBAMIDE®) and topical diclofenac (VOLTAREN®) Emulgel 1% for improving the incidence of
Hand-foot syndrome in histologically proven breast cancer Egyptian patients receiving single
agent chemotherapy Capecitabine (XELODA ®) and Its effect on improving patients' quality of
life.