To determine the effect of capsaicin upon serial transcranial Doppler (TCD) markers of
cerebral blood flow (CBF). Methods Serial TCD testing in 30 participants with cerebrovascular
risk factors. Capsaicin doses .66 and .99 μMol. Outcomes: peak systolic and end-diastolic
velocities in the middle cerebral artery (MCA), mean velocity (MV), pulsatility index (PI),
CBF index, arterial pressure, and perceived pungency (PP) in five minutes intervals up to 20
minutes.