Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy

• Status: Terminated
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Captopril is a drug that may be able to decrease side effects caused by radiation therapy, and may improve the quality of life of patients with non-small cell lung cancer or limited-stage small cell lung cancer.

PURPOSE: This randomized phase II trial is studying how well captopril works in decreasing side effects and improving the quality of life in patients who have received radiation therapy with or without chemotherapy for stage I, stage II, or stage IIIB non-small cell lung cancer or limited-stage small cell lung cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radiation Therapy Oncology Group
• Collaborators: National Cancer Institute (NCI); NRG Oncology
• Treatments: Captopril

Criteria

DISEASE CHARACTERISTICS:

• One of the following histologically or cytologically confirmed diagnoses:

• Stage II-IIIB non-small cell lung cancer (NSCLC)

• Stage I central NSCLC

• No peripheral coin lesions

• Limited stage small cell lung cancer

• Nonmetastatic disease that is receiving radiotherapy and the target is confined to a single radiotherapy treatment area

• Planning to receive radiotherapy

• At least 45 Gy to be delivered to the target volume

• More than 25% of total lung volume to receive > 20 Gy if receiving radiotherapy alone

PATIENT CHARACTERISTICS:

Age

• 18 and over

Performance status

• Zubrod 0-1

Hematopoietic

• Absolute granulocyte count greater than 1,000/mm^3

• Platelet count greater than 75,000/mm^3

• Hemoglobin greater than 9.0 g/dL (transfusion allowed)

Hepatic

• Bilirubin less than 1.5 mg/dL

• Serum glutamate oxaloacetate transaminase (SGOT) less than 2 times normal

Renal

• Blood urea nitrogen (BUN) less than 25 mg/dL

• Creatinine less than 1.6 mg/dL

• Urine protein less than 10 mg/dL

• Urine glucose negative

Cardiovascular

• Systolic blood pressure greater than 110 mm Hg

• Diastolic blood pressure greater than 60 mm Hg

Other

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• Sodium normal

• Potassium normal

• No collagen vascular disease (e.g., lupus or scleroderma)

• Rheumatoid arthritis allowed

• No known hypersensitivity to ACE inhibitors

PRIOR CONCURRENT THERAPY:

Biologic therapy

• Not specified

Chemotherapy

• Induction or concurrent chemotherapy allowed either during radiotherapy or during therapy with captopril

• No concurrent methotrexate

Endocrine therapy

• Not specified

Radiotherapy

• See Disease Characteristics

Surgery

• Prior pulmonary lobectomy or segmentectomy allowed

• No prior pneumonectomy

Other

• No concurrent angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor antagonists for hypertension or congestive heart failure

• No concurrent lithium

• No concurrent procainamide