Carbetocin Versus Oxytocin for the Prevention of Postpartum Hemorrhage in Emergency Caesarean Delivery
Status:
Completed
Trial end date:
2018-08-01
Target enrollment:
Participant gender:
Summary
Postpartum haemorrhage keeps to be the leading cause of maternal mortality in middle and
low-income countries, including Iraq. Much advancement had been made in the field of
treatment for postpartum haemorrhage but no much progress had been made in the field of
prevention, where one of its main component is the administration of uterotonic, preferably
oxytocin, immediately after birth of the baby.
In many low- and middle income countries, the efficacy of oxytocin cannot be assured since
access to sustained cold-chain is unavailable. Regarding the other uterotonics; ergometrine
degrades when exposed to heat or light. Misoprostol degrades rapidly when exposed to
Moisture.
Innovation in the manufacture of carbetocin had meet the stability requirements for hot and
humid climates.
This study had been accomplished to evaluate the uterotonic effect of carbetocin compared
with oxytocin for the prevention of postpartum haemorrhage in emergency caesarean delivery.
Looking if carbetocin is superior to oxytocin in term of reduction in the need for additional
uterotonic agents or the occurrence of PPH.