Carbetocin Versus Oxytocin for the Prevention of Postpartum Hemorrhage in Emergency Caesarean Delivery

• Status: Completed
• Trial end date: 2018-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

Postpartum haemorrhage keeps to be the leading cause of maternal mortality in middle and low-income countries, including Iraq. Much advancement had been made in the field of treatment for postpartum haemorrhage but no much progress had been made in the field of prevention, where one of its main component is the administration of uterotonic, preferably oxytocin, immediately after birth of the baby.

In many low- and middle income countries, the efficacy of oxytocin cannot be assured since access to sustained cold-chain is unavailable. Regarding the other uterotonics; ergometrine degrades when exposed to heat or light. Misoprostol degrades rapidly when exposed to Moisture.

Innovation in the manufacture of carbetocin had meet the stability requirements for hot and humid climates.

This study had been accomplished to evaluate the uterotonic effect of carbetocin compared with oxytocin for the prevention of postpartum haemorrhage in emergency caesarean delivery. Looking if carbetocin is superior to oxytocin in term of reduction in the need for additional uterotonic agents or the occurrence of PPH.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Al-Kindy College of Medicine
• Collaborator: Elweyia Maternity Teaching Hospital
• Treatments: Carbetocin; Oxytocin

Criteria

Inclusion Criteria:

• Patients age ≥18 years

• Singleton pregnancy

• Full term gestation

• Emergency cesarean section during labor

Exclusion Criteria:

• Cases of coagulopathy

• Drug hypersensitivity

• Medical diseases as; cardiac, hypertension, liver, renal or endocrine diseases

• Uterine fibroids

• Suspected placental pathology (accreta, previa or abruptio)

• General anesthesia

• Longitudinal uterine incision