Post-partum hemorrhage (PPH) is a major cause of maternal death worldwide. Oxytocin is the
most commonly uterotonic drug used to prevent and treat PPH in North America, however, there
are some limitations to its use. Oxytocin has a very short duration of action, which requires
a continuous infusion to achieve sustained uterotonic activity. The Society of Obstetricians
and Gynecologists of Canada (SOGC) has recently recommended a single 100mcg dose of
carbetocin at elective Cesarean delivery to promote uterine contraction and prevent post
partum hemorrhage (PPH), in lieu of the more traditional oxytocin regimens. Carbetocin lasts
4 to 7 times longer than oxytocin, with a similar side effect profile and apparent greater
efficacy rate. However, a dose response to determine the minimum effective dose of carbetocin
has not yet been published.
We hypothesize that a dose-response study will establish the minimum dose of carbetocin
required to produce appropriate contractility in 95% of the women (ED95) undergoing elective
cesarean delivery.
Phase:
N/A
Details
Lead Sponsor:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital