Cardiac Effects of Oxytocin Administrated During Cesarean Section, Signs of Myocardial Ischemia
Status:
Completed
Trial end date:
2008-07-01
Target enrollment:
Participant gender:
Summary
Oxytocin has cardio vascular effects as hypotension, tachycardia and possibly coronary spasm.
The uterotonic effect of the drug is used during cesarean section, to minimize blood loss.ECG
changes suggestive of cardiac ischemia (ST depression) has been showed in previous studies of
patients undergoing cesarean section i regional anaesthesia. The effect of oxytocin on this
outcome has not been investigated to any extent.
In the current study, we tested the hypothesis that there was no difference in occurrence of
ECG changes (ST segment depression) between two doses of oxytocin. Participants were
randomized to receive either 5 or 10 units of oxytocin in a double blinded fashion.
Main outcome measure is occurrence of significant ST depression on ECG. Secondary outcome
measures are mean arterial pressure, heart rate, blood loss, symptoms as chest pain,
shortness of breath and feeling of heaviness on the chest.