Cardiac Energetics and Function in Normal Human Ageing

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Normal aging is characterized by altered cardiovascular function. Our preliminary data with MR imaging and spectroscopy in normal subjects without cardiovascular disease or hypertension show that age-related cardiac dysfunction is characterized initially by impaired relaxation of the heart (40 - 60 years), and then at > 60 years altered contraction and impaired myocardial energetics. For the first time, the investigators will test whether the functional and energetic effects of normal aging can be reversed by acutely reducing stiffness of peripheral blood vessels using an ACE inhibitor. This will potentially have important insights into how normal aging affects the heart, and how potential treatments could be used to attenuate this process.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Newcastle-upon-Tyne Hospitals NHS Trust
• Treatments: Ramipril

Criteria

Inclusion Criteria:

• Male and female subjects between the ages of 20 and 80 years

Exclusion Criteria:

• Any cardiovascular condition including hypertension, or on any cardiovascular therapy.

• Blood Pressure > 150 mmHg systolic, and/or > 90 mmHg diastolic

• Claustrophobia

• Implanted metal prosthesis

• Chronic renal failure requiring dialysis

• Diabetes mellitus.