Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea)

• Status: Withdrawn
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients with both sleep apnea and COPD have overlap syndrome, but their optimal management is not known. We plan to conduct a randomized trial of of bi-level PAP vs. night time oxygen to asses the impact of intervention on cardiac MRI and biomarkers.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brigham and Women's Hospital
• Collaborator: Massachusetts General Hospital

Criteria

Inclusion Criteria:

• Both men and women with age more than 18 years.

• Known diagnosis of COPD (GOLD stage 2 or higher).

Exclusion Criteria:

• Already using CPAP or BPAP device.

• Estimated GFR <30 ml/min/1.73 m2 or on hemodialysis.

• Women known to be pregnant or planning to be pregnant in next 6 months.

• Cardiac pacemaker, metallic heart valves, metallic implants, claustrophobic.

• Chronic atrial fibrillation or frequent premature ventricular contractions.

• Using lipid-lowering medications, aspirin, oral steroids, steroid-sparing medications or anti-oxidant vitamin supplements.

• If taking sildenafil or related drugs, unable to stop it within 48 hours of the study visit.

• Contraindications to stress cardiac testing: acute myocardial infarction within 48 hours, unstable angina not yet stabilized with medical therapy, ongoing chest pain, active broncho-constriction, uncontrolled cardiac arrhythmia, symptomatic severe aortic stenosis, aortic dissection, acute pulmonary embolism or pericarditis.

• Uncontrolled COPD or acute COPD exacerbation.

• Known chronic inflammatory diseases like lupus or active infection.