Cardiac Output Changes in Cesarean Section

• Status: Unknown status
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

Since 2011, phenylephrine was recommended as the preferred drug to maintain blood pressure in obstetric anesthesia.Phenylephrine, an α adrenoceptor agonist, can induce peripheral vasoconstriction to maintain blood pressure, while reflexly decrease heart rate and result in cardiac output (CO) reduction.Norepinephrine acts not only as an α adrenoceptor receptor agonist, but also as a weaker β adrenergic receptor agonist. It can elevate blood pressure the same asphenylephrine, meanwhile produce positive inotropic effect including increasing heart rate.Thus, the administration of norepinephrine can maintain blood pressue and avoid the decline of CO. The purpose of this study is to evaluate the effect of norepinephrine and phenylephrine on maternal CO in cesarean section by transesophageal echocardiography.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: RenJi Hospital
• Treatments: Norepinephrine; Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

1. age >=18 years,<=40 years;

2. height 150-180 cm;

3. weight 55-80 kg;

4. full-term gestation (>36 wk and <41 wk)

5. singleton pregnancy undergoing elective cesarean section under CSEA

Exclusion Criteria:

1. contraindications to spinal anesthesia;

2. patients with any complicated pregnancy;

3. fetal compromise;

4. need of emergency;

5. in labor