Cardiac Output Response to Vasopressin Infusion In Abdominal Surgery Patients Under Mechanical Ventilation

• Status: Recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: All

Summary

In this study, the investigators propose to explore the hemodynamic variations induced by vasopressin and its influence on cardiac output, mean systemic pressure, and venous return resistance measured through cardiopulmonary interactions, according to the approach proposed by Guyton, in patients undergoing major abdominal surgeries.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Clermont-Ferrand
• Treatments: Arginine Vasopressin; Vasopressins

Criteria

Inclusion Criteria:

• Adults above 18

• Planned for a major abdominal surgery under general anesthesia

• Under mechanical ventilation

• Presence of a central venous and arterial lines allowing transpulmonary thermodilution cardiac output measurement

• Patient's consent with a social insurance

Exclusion Criteria:

• Do not consent to participate

• History of heart attack, arteriopathy or aneurysm

• Contraindication to use transpulmonary thermodilution to measure cardiac output :

• coagulopathy

• cardiac arrythmia

• presence of pace-maker or defibrillator

• severe valvulopathy

• Patients with Acute Respiratory Distress Syndrome (according to Berlin criteria)

• History of arterial hypertension (treated or not)

• History of seizure, chronic headache, asthma or heart failure

• Left Ventricular Ejection Fraction (LVEF) < 45% or right ventricular dysfunction

• History of pulmonary lobectomy or surgery

• History of restrictive or obstructive pulmonary disease

• Body Mass Index (BMI) < 15 or > 40 kg/m²

• Pregnancy

• Known allergy to vasopressin

• Patients under protection of justice (guardianship, curators...)