Cardiac Surgery Neuroprotection Study in Elders

• Status: Completed
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to determine the potential ability of intranasal insulin to prevent post-operative cognitive decline and post-operative delirium in an elderly cardiac surgery population.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Albert Einstein College of Medicine; Albert Einstein College of Medicine of Yeshiva University
• Collaborator: National Institute on Aging (NIA)
• Treatments: Insulin; Insulin Aspart; Insulin degludec, insulin aspart drug combination; Insulin, Globin Zinc; Insulin, Long-Acting

Criteria

Inclusion Criteria:

1. elderly patients (>=65 years old)

2. undergoing elective coronary artery bypass graft and/or valve surgery requiring cardiopulmonary bypass

3. English or Spanish-speaking

Exclusion Criteria:

1. severe dementia, neurodegenerative, or psychiatric disease that prevents patient from living independently at baseline

2. emergent surgery

3. inability to perform cognitive testing (i.e. difficulty hearing or inability to speak)

4. contraindications to intranasal administration of medication