Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone

• Status: Unknown status
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to correlate in an elderly population (≥ 65 years), the different levels of serum TSH, with cardiopulmonary capacity, quality of life, depressive symptoms and cognition. And assess whether the increased serum TSH to the upper half of the normal range, through the use of antithyroid drugs, is associated with improvements in these parameters.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universidade Federal do Rio de Janeiro
• Collaborator: Conselho Nacional de Desenvolvimento Científico e Tecnológico
• Treatments: Hormones; Methimazole

Criteria

Inclusion Criteria:

• Age ≥ 65 years.

• Healthy Men and women

• Registration at the University Hospital Clementino Fraga Filho (HUCFF).

Exclusion Criteria:

• Hypothalamic-pituitary disease

• Congestive cardiac insufficiency, chronic renal failure, acute renal failure, stroke, chronic obstructive pulmonary disease, asthma, cancer and / or cirrhosis.

• Diseases of the aorta, peripheral vascular disease, coronary artery disease (including angina, history of prior myocardial infarction or angina, or history of cardiac catheterization and angioplasty).

• Use of corticosteroids, amiodarone or dopamine, as well as any drug that interferes with the levels of thyroid hormones and / or thyroid function.

• Use of drugs that interfere with autonomic adaptation mechanism, such as beta-blockers, prolopa and calcium channel blockers. Hypertensive patients without use of such drugs may be included.

• Patients bedridden, wheelchair or with physical limitations (joint and muscle) to prevent the standing position for at least 20 minutes and the realization of the cardiopulmonary exercise test.

• Obesity with a body mass index equal or greater than 35 kg/m2.