Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus Ultrafiltration

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The CRUF trial is a prospective randomized monocentric trial comparing different impact of diuretics versus ultrafiltration on renal congestion, plasma refill rate, echocardiographic filling pressures, neurohormonal activation and biomarkers of Acute Kidney Injury (AKI).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Ghent
• Treatments: Diuretics

Criteria

Inclusion Criteria:

• >18 years old

• Severe systolic heart failure with ejection fraction <40%

• And Hospitalisation for decompensated heart failure

• And New York Heart Association (NYHA) III or IV

• And 1 of the following:

• Jugular vein distension>6cm

• Tissue Doppler mitral annulus lateral>12 or medial>15

• Chest X-ray: pulmonary edema or pleural effusion

Exclusion Criteria:

• Need for inotropic or vasopressive agents

• Use of intravenous (IV) contrast media

• Acute coronary syndrome

• Need of dialysis

• Severe co-morbidity

• Contra-indications for anticoagulation

• Pregnancy