Cardiovascular Magnetic Resonance for the Occluded Infarct-Related Artery Treatment

• Status: Terminated
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether opening an occluded infarcted artery 3-28 days after an acute myocardial infarction in high-risk asymptomatic patients with preserved infarct zone viability improves left ventricular systolic function and volumes at 6 months follow-up. The secondary purpose is to assess the changes in myocardial tissue characteristics after late percutaneous coronary intervention (PCI).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Institute of Cardiology, Warsaw, Poland
• Treatments: Adrenergic Agents; Adrenergic Antagonists; Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mineralocorticoid Receptor Antagonists; Platelet Aggregation Inhibitors

Criteria

Inclusion Criteria:

• Enrollment 3-28 days after an acute myocardial infarction.

• Infarct related artery occlusion (TIMI 0 or 1).

• High risk: left ventricular ejection fraction (LVEF)<50% or LVEF>50% and proximal coronary occlusion.

• Preserved infarct zone viability (necrosis transmurality <50% in at least 4 segments out of 17 according to AHA classification).

Exclusion Criteria:

• Unstable clinical condition