Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding

• Status: Recruiting
• Trial end date: 2030-12-10
• Target enrollment: 0
• Participant gender: All

Summary

Carvedilol versus endoscopic band ligation for primary prophylaxis of oesophageal variceal bleeding in cirrhotic patients with arterial hypertension

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sherief Abd-Elsalam
• Treatments: Carvedilol

Criteria

Inclusion Criteria:

• • Aged >18 years

• Cirrhotic patients with arterial hypertension

• Endoscopic evidence of medium/large-sized esophageal varices

Exclusion Criteria:

• • History of variceal bleeding or previous primary prevention of varices.

• Portal vein thrombosis or previous porto-systemic shunts as TIPS.

• Patients on drugs affecting portal pressure (beta blockers, nitrates).

• Advanced cardiovascular disease including acute myocardial infarction, atrio-ventricular block, congestive heart failure, chronic peripheral ischemia, severe bradycardia.

• Patients with severe respiratory diseases (COPD, bronchial asthma).

• Uncontrolled diabetes mellitus

• Renal impairment

• Hepatocellular carcinoma

• Allergy to carvedilol

• Pregnancy or lactation