Severe burn is associated with a wide array of stress, metabolic, and physiologic processes
in an attempt to restore homeostasis. The catecholamine induced stress response following
severe burns is particularly exaggerated and manifests detrimentally as inflammation, insulin
resistance, hypermetabolism, and associated profound protein catabolism. The investigators
hypothesize that catecholamine blockade will lead to restored IR signaling and result in
improved post-burn morbidity. The investigators will further determine the molecular
mechanisms mediating these effects.