Catheter-Directed Thrombolysis Versus Anticoagulation Monotherapy in Intermediate-High Risk PE
Status:
Terminated
Trial end date:
2020-05-02
Target enrollment:
Participant gender:
Summary
In an open-label parallel groups blinded-endpoint randomized clinical trial, the
investigators aim to assess the safety and efficacy of conventional catheter-directed
thrombolysis (CDT) vs anticoagulation monotherapy on outcomes of patients with acute
intermediate-high risk pulmonary embolism. The investigators hypothesize that CDT will have a
superior efficacy and safety compared with anticoagulation-only therapy regarding the
proportion of patients with a right ventricle to left ventricle (RV/LV) ratio > 0.9 at a
3-month follow-up by an imaging core laboratory, major bleeding, severe thrombocytopenia, or
vascular access complication.