Cefazolin-Lidocaine Combination Solution to Reduce Antibiotic Pain
Status:
Unknown status
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
In retinal surgery, endophthalmitis is a sight-threatening eye infection that could
complicate patient vision after the operation. At Toronto Western Hospital, for retinal
surgery (operating at the back of the eye) it is common practice to administer an antibiotic
(cefazolin) at the end of surgery, to reduce the risk of post-operative endophthalmitis. The
antibiotic is administered by injection underneath the part of the eye called the
conjunctiva. However, this antibiotic injection is often associated with high levels of
post-operative pain. Previous studies have observed a reduction of this pain by injecting an
anesthetic (lidocaine) in the subconjunctival space before the antibiotic. This study will
seek to examine whether mixing 2% lidocaine with cefazolin before its injection will reduce
post-operative pain in the retinal surgery setting.