Celebrex - Cervix: Celecoxib in the Treatment of Patients With Locally Advanced Carcinoma of the Cervix
Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
This is a phase I/II study to evaluate the safety and toxicity of celecoxib in combination
with standard concurrent cisplatin and radiotherapy in women with locally advanced cervix
cancer. In addition, we aim to determine the effect of celecoxib (Celebrex) on tumour
oxygenation, interstitial fluid pressure, COX-2 levels, prostaglandin E2 levels, angiogenesis
and apoptosis.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University Health Network, Toronto
Collaborators:
NCIC Clinical Trials Group Princess Margaret Hospital, Canada